Akademik Veri Yönetim Sistemi
FRESENIUS ENVIRONMENTAL BULLETIN, cilt.20, sa.4, ss.945-952, 2011 (SCI-Expanded)
This study was aimed at screening selected Turkish medicinal plants for their in vitro antimicrobial activity. Crude extracts (178) were obtained from the flowers, leaves and stems of 22 different plant specieses (Achillea biebersteini, Achillea setacea, Anthemis tinctoria, Inula montbretiana, Cistus creticus, Pelargonium endlicherianum, Hypericum perforatum, Hypericum confertum subsp. confertum, Marrubium astracanicum subsp. astracanicum, Marrubium vulgare, Mentha pulegium, Teucrium chamaedrys subsp. chamaedrys, Teucrium polium, Thymus longicaulis subsp. longicaulis var. subisophyllus, Thymus longicaulis, Thymus sibthorpii, Salvia cyanescens, Epilobium hirsutum, Paeonia peregrina, Galium verum subsp. verum, Verbascum cheiranthifolium) using ethanol, acetone and ether as solvents. Results showed that all of the plants tested possessed antimicrobial activity against at least one of the test microorganism with inhibition zones that ranged from 7 to 30 mm (1000 mu g/disk). The most active plant that showed broad antimicrobial activity spectrum against all test microorganisms was T sibthorpii. H. confertum subsp. confertum, G. verum subsp. verum, A. tinctoria, M. pulegium, I. montbretiana, P. peregrina, E. hirsutum, T longicaulis and C. creticus1 and 2, all formed broader inhibition zones than control antibiotics did. The most susceptible test strains against plant extracts were Staphylococcus epidermis, S. aureus, Shigella ssp. and Escherichia coli, the most resistant yeast was Candida albicans. While the ethanol was the most active solvent to extract biological active compounds, flower parts of plants were more active than the leave and stem parts. While the minimum inhibitory concentration of selected active extracts ranged from 62.5 to 1000 mu g/ml, their minimum bactericidal/ fungicidal concentration ranged from 125 to 1000 mu g/ml. To the best of our knowledge, this is the first report on antimicrobial principles of H. confertum subsp. confertum, V. cheiranthifolium, S. cyanescens, T. sibthorpii, M. astracanicum subsp. astracanicum, and I. montbretiana.