This work is an application of the response surface methodology (RSM) to determine the effects of operational parameters on the heterogeneous Fenton-type oxidation of the burazol blue ED (BB). The study was conducted using a Fe (III) sepiolite catalyst in the presence of hydrogen peroxide (H2O2) in a batch process. The effects of operational parameters such as the pH of the reaction, catalyst concentration, stirring speed, and reaction time were examined under the following conditions: a temperature of 25 degrees C, 100ppm initial dye concentration, and 0.5mM H2O2 concentration. Because of the significant curvature effect, central composite design (CCD) was preferred to full-factorial experimental design for the simultaneous optimization of color and chemical oxygen demand (COD) removals. Optimized reaction conditions were established as pH 2, 1g/250mL catalyst dose, 250-rpm stirring speed, and 60-min reaction time. Contour plots and a desirability function were used to find the local points of optimization. After conformation, under the optimized reaction conditions, 96% color and 75% COD removals were obtained experimentally. These values were in the prediction interval and were in agreement with the quadratic polynomial model predictions.