The therapeutic potential of amifostine on cyclophosphamide-induced testicular dysfunction in rats: An experimental study

Kaya C., Baseskioglu A. B., YİĞİTASLAN S., ÖZATİK F. Y., ÖZATİK O., USLU S.

INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE, cilt.17, sa.4, ss.245-252, 2019 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.18502/2
  • Dergi Adı: INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.245-252
  • Anahtar Kelimeler: Amifostine, Cyclophosphamide, Rat, Testis, TESTIS, DOXORUBICIN, PROTECTS, INJURY, ACID, DRUG
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background: Cyclophosphamide (CP) is a well-known alkylating anticancer agent used in the treatment of various malignant and non-malignant tumors. CP may also cause a variety of adverse effects, including reproductive toxicity. Amifostine is known as a cytoprotective drug having antioxidant properties.