Effects of Gabapentin on Carrageenan-Induced Inflammation, Acute Phase Reactants and Gastric Mucus Secretion in Rats

Kılıç, FATMA; Aydın, ŞULE; Yildirim, CAFER; Donertas, FATMA; Oner, KEVSER; Kaygısız, BİLGİN

doi:10.5152/eurjther.2018.543

Effects of Gabapentin on Carrageenan-Induced Inflammation, Acute Phase Reactants and Gastric Mucus Secretion in Rats

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Kılıç F. S., Aydın Ş., Yildirim C., Donertas B., Oner S., Kaygısız B.

EUROPEAN JOURNAL OF THERAPEUTICS, vol.25, pp.23-27, 2019 (ESCI)

Publication Type: Article / Article
Volume: 25
Publication Date: 2019
Doi Number: 10.5152/eurjther.2018.543
Journal Name: EUROPEAN JOURNAL OF THERAPEUTICS
Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
Page Numbers: pp.23-27
Eskisehir Osmangazi University Affiliated: Yes

Abstract

Objective: Gabapentin (GBP), which was first developed as an anticonvulsant agent, has recently gained great attention considering its pain relieving and anti-inflammatory effects. The aim of the present study was to investigate the anti-inflammatory effect of GBP on carrageenan (CAR)-induced paw edema and its gastric side effects by determining gastric mucus secretion in rats.