Efficacy of Leukotriene Antagonists as Concomitant Therapy in Allergic Rhinitis

CİNGİ C., Gunhan K., Gage-White L., Unlu H.

LARYNGOSCOPE, cilt.120, sa.9, ss.1718-1723, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 120 Sayı: 9
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1002/lary.20941
  • Dergi Adı: LARYNGOSCOPE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1718-1723
  • Anahtar Kelimeler: Allergic rhinitis, leukotrienes, montelukast, leukotriene receptor antagonist, DOUBLE-BLIND, 180 MG, FEXOFENADINE, MONTELUKAST, EXPRESSION, HUMANS, MUCOSA
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objectives/Hypothesis: The symptoms of allergic rhinitis result from an immunoglobulin E-dependent mast cell activation cascade, marked by the release of inflammatory mediators, including histamine. Patients with perennial allergic rhinitis also have elevated levels of cysteinyl leukotrienes (CysLTs) in nasal lavage fluid. Histamine and CysLTs produce different responses in the pathogenesis of allergic rhinitis, and this study tested the hypothesis that the effects of combined antihistamine and leukotriene antagonist therapy would be more effective than antihistamine alone.