Efficacy of sublingual immunotherapy for house dust mite allergic rhinitis

CİNGİ C., Bayar Muluk N., Ulusoy S., Acar M., ŞİRİN S., YALDIZ ÇOBANOĞLU H. B., ...Daha Fazla

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, cilt.272, sa.11, ss.3341-3346, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 272 Sayı: 11
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s00405-014-3444-1
  • Dergi Adı: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3341-3346
  • Anahtar Kelimeler: Sublingual immunotherapy (SLIT), Allergic rhinitis (AR), Rhinitis Quality of Life Questionnaire (RQLQ), House dust mite (HDM), DOUBLE-BLIND, ASTHMA, CHILDREN
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

In the present study, we investigated the outcomes of sublingual immunotherapy (SLIT) in house dust mite-induced allergic rhinitis (HDM-AR) patients. In this prospective, multicentric study, 186 patients with AR who had positive skin prick test results for HDMs were included. The patients were administered SLIT using Staloral 300 for 1 year. Evaluation of the patients regarding symptom scores, clinical findings and Rhinitis Quality of Life Questionnaire (RQLQ) scores was performed at baseline, and then at 6 and 12 months of therapy. Our results showed that, for all of the evaluated items (symptom scores, clinical findings and RQLQ scores), 12-month values were significantly lower than those at 6 months and baseline. Similarly, 6-month values were significantly lower than those at baseline. There were no complications in any of our patients. SLIT for HDM-AR is a treatment modality that can be used safely. We obtained better results than expected, and the treatment showed a positive psychological effect; the patients believed that SLIT was the final step of treatment and, which made them feel better.