Akademik Veri Yönetim Sistemi
10. Anatomi Kış Günleri, Hatay, Türkiye, 17 Mart 2022, (Özet Bildiri)
ABSTRACT. Objective: Major depressive disorder is a disease influencing patients daily-life functionality by altering emotional and cognitive skills and its prevelance was reported as high as %21 worldwide. Aim of this study is to evaluate brain sections related to cortico-limbic network which is involved in major depressive disorder pathogenesis. Methods: Study included 33 patients with major depressive disorder diagnosed in Bal›kesir University Faculty of Medicine psychiatry department. Control group involved 33 healthy adult individual. Participants magnetic resonance images obtained from clinical arhive and cortico-limbic brain section volumes measured automatically by using atlas-based parcellation method. Participants Hamilton Depression Scale scores were obtained in clinical admission. Data were normally distributed. Measured brain volumes, parameters related to prognosis of patients and Hamilton scale scores has been statistically analized using Student’s t-test and pearson correlation coefficient. Results: Volume loss observed in evaluated areas were: %18 and %13 on right and left subgenual gyrus cinguli anterior respectively, %10 and %13 on right and left dorsal gyrus cinguli anterior respectively, %10 on right hippocampus, %11 on bilateral posterior part of gyrus frontalis superior, %14 and %11 on right and left posterior part of gyrus frontalis medius respectively and % 10 on left amygdala. All results were statistically significant. Pearson correlation analisis has shown that volume loss and Hamilton scale scores were negatively correlated. Conclusion: The significance of this study is that it shows volume loss in specific cortical motor areas with cortico-limbic atrophy. Even though motor area atrophy in depression research is not a popular topic, there are studies which show functional relevance related to depressive disorders in motor areas which we observed atrophy in this study. Thus these results may provide insights on major depression disorder pathogenesis and contribute to neuroanatomy literature on cognitive and emotional circuits. Keywords: major depressive disorder, MR imaging, atlasbased method, cortical volume