Effects of cyclosporin A on chromosomes and some serum enzymes in rats
Turkish Journal of Medical Sciences, cilt.24, sa.3, ss.181-184, 1995 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 3
- Basım Tarihi: 1995
- Dergi Adı: Turkish Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.181-184
- Anahtar Kelimeler: chromosomes, cyclosporin A, serum enzymes
- Eskişehir Osmangazi Üniversitesi Adresli: Evet
Özet
The effects of different doses of cyclosporin A (2.5, 10, 25, 50 mg/kg/day) on chromosomes and serum enzymes in rats were investigated. Cyclosporin A (all doses) had no numerical effect on chromosomes. There was a dose-dependent increase of chromatid-type breakage, serum SGOT, SGPT, ALP and ASP levels according to the control. These increases were especially noted in the 50 mg/kg/day group.