Effects of genetic variations in the genes encoding NOD1 and NOD2 on type 2 diabetes mellitus and insulin resistance

ÖZBAYER C., KURT H., Kebapci M. N., Gunes H. V., Colak E., DEĞİRMENCİ İ.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, cilt.42, sa.1, ss.98-102, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1111/jcpt.12482
  • Dergi Adı: JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.98-102
  • Anahtar Kelimeler: insulin resistance, NOD1, NOD2, rs2066847, rs5743336, type 2 diabetes, INNATE IMMUNITY, CROHNS-DISEASE, INFLAMMATORY DISEASES, POLYMORPHISM, NOD2/CARD15, OBESITY, LINK, SUSCEPTIBILITY, NOD1/CARD4, EXPRESSION
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

What is known and objectiveNucleotide-binding oligomerization domain (NOD) 1 and NOD 2 are members of the NOD-like receptor (NLR) family and contain a caspase recruitment domain. NLRs are located in the cytosol, bind bacterial and viral ligands and play a key role in the realization of innate and adaptive immune response, inflammation, apoptosis and reactive oxygen species generation. Insulin resistance (IR) is a leading cause of type 2 diabetes mellitus (T2DM) and associated with obesity, inflammation and pro-inflammatory responses. NOD1 and NOD2 gene variants may affect the risk of chronic inflammation, insulin resistance and T2DM by shifting the balance between pro- and anti-inflammatory cytokines. The aim of our study was to determine whether the NOD1/2 gene variants might contribute to the risk of T2DM and IR.