Synthesis and anticonvulsant activity of some alkanamide derivatives

TARİKOĞULLARI DOĞAN A. H., KILIÇ F. S., Erol K., Pabuccuoglu V.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.60, sa.10, ss.593-598, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 10
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1055/s-0031-1296331
  • Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.593-598
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

A group of N-phenylacetamide, N-phenylpropanamide and N-benzylamide derivatives bearing 5-membered heterocyclic rings such as pyrazole, 1,2,4-triazole and imidazole rings at omega position were synthesized and their anticonvulsant activity was evaluated in the maximal electroshock test. The results indicated that the 1,2,4-triazole ring leads to superior activity than the pyrazole ring and inserting a CH2 group into the anilide structure leading to N-benzyl derivatives did not change the anticonvulsant activity, but caused a noticeable decrease in duration of action. The most active compound was 2-(1H-1,2,4-triazole-1-y1)-N(2,6-dimethylphenyl)acetamide.