Effects of astaxanthin on metastasis suppressors in ductal carcinoma. A preliminary study

Badak B., Aykanat N. E. B., Kacar S., Sahinturk V., Arik D., Canaz F.

ANNALI ITALIANI DI CHIRURGIA, cilt.92, sa.5, ss.565-574, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 92 Sayı: 5
  • Basım Tarihi: 2021
  • Dergi Adı: ANNALI ITALIANI DI CHIRURGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.565-574
  • Anahtar Kelimeler: Breast, cancer, metastasis, PROTEIN-KINASE KINASE-4, BREAST-CANCER, HAEMATOCOCCUS-PLUVIALIS, PROGNOSTIC-SIGNIFICANCE, INHIBITS PROLIFERATION, MASPIN EXPRESSION, MIGRATION, APOPTOSIS, CELLS, GENE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

BACKGROUND: Breast cancer (BC) is a major public health problem diagnosed in more than 2 million women worldwide in 2018, causing more than 600,000 deaths. 90% of deaths due to breast cancer are caused by metastasis. Metastasis is a complex process that is divided into several steps, including separation of tumor cells from the primary tumor, invasion, cell migration, intravasation, vasculature survival, extravasation, and colonization of the secondary site. Astaxanthin (AXT) is a marine-based ketocarotenoid that has many different potential functions such as anti-oxidant, anti-inflammatory and oxidative stress-reducing properties to potentially reduce the incidence of cancer or inhibit the expansion of tumor cells. This study aims to investigate the effects of astaxanthin as a new metastasis inhibitor on T47D human invasive ductal carcinoma breast cancer cell.