Akademik Veri Yönetim Sistemi
2. INTERNATIONAL CANKAYA SCIENTIFIC STUDIES CONGR, Ankara, Türkiye, 28 - 29 Eylül 2023, ss.465-466, (Özet Bildiri)
Evaluation of viscoelastic coagulation by thromboelastography (TEG) analysis has been
gaining importance from the past. Experimental and clinical studies have been carried out in
human medicine for many years. The positive results obtained have also expanded the use of
TEG in veterinary medicine. Firstly, coagulation analyzes with TEG in animals were actually performed in experimental
animal models created for human medicine. However, the fact that TEG can detect
hypocoagulation and hypercoagulation states and evalute fibrinolysis has enabled it to be used
in other animal species. Viscoelastic testing systems used in veterinary medicine are TEG and
rotational thromboelastometry (ROTEM) methods. They are based on the same methodology
but have some minor differences. Measurements often included in TEG studies in dogs are R
(reaction time), K (clotting time from the end of R until the TEG curve reaches a deviation of
20 mm), angle (angle of separation of the curve), MA (maximum amplitude of the curve),
and G (exponential reflection of MA indicating clot stability). In measurements made with
TEG, whole blood is always used, which provides superiority to coagulation tests performed
with traditional plasma. Thus, measurements are made with more components that contribute
to coagulation, allowing hemostasis to be evaluated as a whole. Reference and clinical studies
have been conducted in dogs using activators such as kaolin and tissue factor (TF). The
results of experimental studies conducted in dogs suggest that the use of the TEG method in
clinical cases will contribute to the evaluation of coagulation. Clinical studies with TEG have
been mostly reported in dogs. In this way, there is a research area that provides examples and
comparison opportunities for clinical studies. It becomes difficult to evaluate the effectiveness
of studies on animal species such as cats and horses, which are also cared for by humans
individually, due to the lack of studies. In clinical cases in dogs, coagulation measurements
made with TEG can identify hypercoagulation states that cannot be detected by traditional
coagulation tests. At this stage, changes in the treatment protocol or information regarding
prognosis could be obtained. However, due to the variation in TEG measurements in dogs, as
in many animal species, it is recommended that each laboratory conduct its own reference
studies. In this study, it was aimed to evaluate the effectiveness of coagulation measurement
in routine clinical use based on TEG studies conducted in dogs.