Effects of ivabradine and beta-blocker therapy on dobutamine-induced ventricular arrhythmias

Mert K. U., Mert G. Ö., Morrad B., Tahmazov S., Mutlu F., Çavuşoğlu Y.

KARDIOLOGIA POLSKA, cilt.75, sa.8, ss.786-793, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 75 Sayı: 8
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5603/kp.a2017.0094
  • Dergi Adı: KARDIOLOGIA POLSKA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.786-793
  • Anahtar Kelimeler: ivabradine, heart failure, arrhythmias, CONGESTIVE-HEART-FAILURE, NERVOUS-SYSTEM, RATE REDUCTION, HCN CHANNELS, I-F, MORTALITY, ISCHEMIA, DEATH, TRIAL
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background: Indirect evidences suggest that the If blocker ivabradine may exert an antiarrhythmic effect in ventricular myocardium in heart failure (HF) patients by inhibiting spontaneous depolarisations, but the clinical relevance of this mechanism is not known. Dobutamine (DOB) has been known to increase heart rate and the incidence of cardiac arrhythmias.