Pregabalin Attenuates Carrageenan-Induced Acute Inflammation in Rats by Inhibiting Proinflammatory Cytokine Levels

Kılıç F. S., Kaygısız B., Aydın Ş., Yildirim C., Karimkhani H., Oner S.

EURASIAN JOURNAL OF MEDICINE, vol.50, pp.156-159, 2018 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50
  • Publication Date: 2018
  • Doi Number: 10.5152/eurasianjmed.2018.17261
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.156-159
  • Keywords: Pregabalin, inflammation, anti-inflammatory effect, cytokines, rat, HYPERSENSITIVITY, GABAPENTIN, MECHANISMS, EXTRACT, MODELS, ACID, MICE
  • Eskisehir Osmangazi University Affiliated: Yes


Objective: Pregabalin (PGB) is a compound used in the treatment of epilepsy, anxiety, and neuropathic pain. Experimental data also indicate that PGB can reduce inflammatory pain. We aimed to investigate the anti-inflammatory effects of PGB on carrageenan (CAR)-induced paw edema and its effects on tumor necrosis factor-alpha (TNF-alpha) and interleukine-1 beta (IL-1 beta) acting as acute phase cytokines in inflammation, and antiinflammatory cytokine IL-10, in rats.