EURASIAN JOURNAL OF MEDICINE, vol.50, pp.156-159, 2018 (ESCI)
Article / Article
EURASIAN JOURNAL OF MEDICINE
Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
Pregabalin, inflammation, anti-inflammatory effect, cytokines, rat, HYPERSENSITIVITY, GABAPENTIN, MECHANISMS, EXTRACT, MODELS, ACID, MICE
Eskisehir Osmangazi University Affiliated:
Objective: Pregabalin (PGB) is a compound used in the treatment of epilepsy, anxiety, and neuropathic pain. Experimental data also indicate that PGB can reduce inflammatory pain. We aimed to investigate the anti-inflammatory effects of PGB on carrageenan (CAR)-induced paw edema and its effects on tumor necrosis factor-alpha (TNF-alpha) and interleukine-1 beta (IL-1 beta) acting as acute phase cytokines in inflammation, and antiinflammatory cytokine IL-10, in rats.