Pharmacoeconomic evaluation of caspofungin versus liposomal amphotericin B in empirical treatment of invasive fungal infections in Turkey


Turner S. J., Senol E., Kara A., Al-Badriyeh D., Kong D. C. M., DİNLEYİCİ E. Ç.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, cilt.42, sa.3, ss.276-280, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.ijantimicag.2013.04.030
  • Dergi Adı: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.276-280
  • Anahtar Kelimeler: Antifungal agents, Caspofungin, Liposomal amphotericin B, Economic evaluation, Invasive fungal infection, Empirical therapy, ANTIFUNGAL THERAPY, FEBRILE NEUTROPENIA, ECONOMIC-EVALUATION, FEVER
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Invasive fungal infections (IFIs) are a major concern within healthcare systems. This pharmacoeconomic study evaluated the use of caspofungin (CAS) versus liposomal amphotericin B (L-AmB) in the empirical treatment of IFIs within the Turkish healthcare system. A decision-analytic model was adopted, utilising data from a randomised, non-inferiority clinical trial and a panel of clinical experts in Turkey. A five-point composite outcome measure was used to evaluate both agents. Sensitivity analyses were performed. In the base-case scenario, CAS was preferred over L-AmB by Turkish Lira (TL) 3961 per patient treated, TL 12 904 per successfully treated patient and TL 3972 per death averted. One-way sensitivity analysis did not change the study outcome. Monte Carlo simulation concluded a 71.0% chance of the outcome favouring CAS. The results were most sensitive to changes in length of stay. This is the first economic evaluation of the empirical treatment of IFIs in Turkey and suggests that CAS is more cost effective than L-AmB. (C) 2013 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.