High nucleostemin expression has a favorable prognostic effect on gastric carcinomas

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Yildirim G. D., Arık D., Yıldız B., Dincer M., Yaşar N. F., Pasaoglu O.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.48, ss.484-490, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48
  • Basım Tarihi: 2018
  • Doi Numarası: 10.3906/sag-1705-165
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.484-490
  • Anahtar Kelimeler: Gastric carcinoma, nucleostemin, prognosis, CELL-CYCLE ARREST, CANCER, P53, PROLIFERATION, MECHANISM, STEM, ARF
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background/aim: Nucleostemin is a nuclear protein that maintains stem cell features and plays a role as a cell proliferation marker. It also participates in cell cycle regulation by interfering with other intracellular proteins. Recent reports have indicated that this protein plays a role in ribosomal biogenesis and genome protection. High expression level of nucleostemin has been reported in some cancer patients. However, the importance of nucleostemin in gastric cancer needs to be addressed. The aim of this study was to investigate nucleostemin expression in gastric cancer and the effects of this expression on prognosis.