Cyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: Protective role of boron

Cengiz M., Şahintürk V., Yildiz S. C., Sahin I. K., Bilici N., Onur Yaman S., ...Daha Fazla

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, cilt.62, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.jtemb.2020.126574
  • Dergi Adı: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Cyclophosphamide, Testicular damage, Apoptosis, Boron, Anti-Oxidant, Lipid per oxidation, GERM-CELL APOPTOSIS, BORIC-ACID, DIETARY BORON, ELLAGIC ACID, DAMAGE, TOXICITY, GENOTOXICITY, METABOLITES, EXPOSURE, BLOOD
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background: Cyclophosphamide (CP) is an alkylating chemotherapeutic drug used in the treatment of many types of cancer. However, as with other chemotherapeutic drugs, the use of CP is limited by the damage to healthy tissues such as testes, bladder and liver as well as cancerous tissue. Boron (B) is a trace element with many biological properties such as antioxidant, anti-apoptotic and anti-lipid per oxidation.