Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity

Turan-Zitouni G., Sivaci M., Kilic F. S., Erol K.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.36, ss.685-689, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0223-5234(01)01252-1
  • Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.685-689
  • Anahtar Kelimeler: antipyrine, triazoles, analgesic activity
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

The synthesis of some triazolyl-antipyrine derivatives starting from 4-chloroacetamidoantipyrine and 3-(aryloxyalkyl)-4-ethyl/phenyl-5-mercapto-1,2,4-triazoles is described. The chemical structures of the compounds were elucidated by IR, H-1-NMR and mass spectral studies. These compounds were tested for analgesic activity. (C) 2001 Editions scientifiques et medicales Elsevier SAS.