Effectiveness of montelukast in pediatric patients with allergic rhinitis


YILMAZ Ö., Altintas D., Rondon C., CİNGİ C., Oghan F.

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, cilt.77, sa.12, ss.1922-1924, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 77 Sayı: 12
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.ijporl.2013.10.006
  • Dergi Adı: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1922-1924
  • Anahtar Kelimeler: Allergic rhinitis, Leukotriene receptor antagonist, Montelukast, Children, LEUKOTRIENE RECEPTOR ANTAGONIST, EXHALED NITRIC-OXIDE, CLINICAL-TRIALS, SCHOOL-AGE, CHILDREN, ASTHMA, PREVALENCE, SCHOOLCHILDREN, TOLERABILITY, CETIRIZINE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Allergic rhinitis (AR) is one of the most common chronic diseases of childhood and carries significant morbidity as well as physical and psychosocial consequences. Therapy aims to alleviate clinical symptoms, prevent complications and improve psychosocial consequences. Leukotrienes which are amongst the main mediators in pathogenesis of AR have chemotactic properties and lead to increased vascular permeability. Thus, leukotriene antagonism may be an effective therapeutic option in treatment of allergic diseases, specifically AR. Montelukast which is a leukotriene receptor type I inhibitor has variable efficacy in children with AR and the guidelines recommend its use in children with seasonal AR aged six years and above. Although its efficacy is inferior to anti-histamines and intranasal corticosteroids, combination treatment may warrant clinical efficacy. Therefore, montelukast may be considered to be a well-tolerated therapeutic option for children with AR with minor side effects though long term results need to be assessed.