Akademik Veri Yönetim Sistemi
UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY, cilt.25, sa.1, ss.7-11, 2026 (ESCI, TRDizin)
Objective: Cribriform architecture has increasingly been recognized as an adverse morphological feature in prostate adenocarcinoma. The present study aimed to describe a novel histopathological subtype of cribriform architecture, termed conglomerated cribriform morphology (CCM), and to investigate its association with clinicopathological parameters and oncological outcomes. Materials and Methods: Radical prostatectomy specimens with Gleason score 7 and cribriform architecture were retrospectively reviewed. All cases were re-evaluated and categorized into two morphological groups: basic cribriform morphology and CCM. Clinicopathological variables and survival outcomes were compared between these groups. Results: A total of 151 patients were included in the study, with a mean age of 67.6 years. CCM was detected in 21.2% of cases. This pattern was significantly associated with higher prostate-specific antigen levels, extraprostatic extension, lymph node metastasis, biochemical recurrence, and distant metastasis. Multivariate Cox regression analysis revealed tertiary Gleason pattern, lymphovascular invasion, and CCM as independent predictors of biochemical recurrence. Patients with CCM had significantly shorter biochemical recurrence-free survival. Conclusion: Cribriform architecture is widely considered an unfavorable feature in prostate cancer. The newly described conglomerated cribriform subtype appears to be a particularly aggressive variant. Recognition of this morphology may contribute to improved prognostic stratification and influence clinical management strategies.