Antinociceptive effects of gabapentin & its mechanism of action in experimental animal studies

KILIÇ F. S., SIRMAGÜL B., YILDIRIM E., Oner S., Erol K.

INDIAN JOURNAL OF MEDICAL RESEARCH, vol.135, no.5, pp.630-635, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 135 Issue: 5
  • Publication Date: 2012
  • Journal Name: INDIAN JOURNAL OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.630-635
  • Keywords: Antinociceptive effect, gabapentin, mice, nNOS, PGE(2), rat hippocampus slices, NITRIC-OXIDE, RAT CEREBELLUM, RECEPTOR, ANTICONVULSANT, ACID
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background & objectives: Several studies have shown the possible analgesic effects of gabapentin, widely used as an antiepileptic. Thus, clinical studies have been carried out especially for neuropathic syndroms. This study was undertaken to investigate experimentally whether gabapentin has analgesic effects in mice and rats.