Putative antinociceptive effect of alpha-tocopherol in mice

KILIÇ F. S., SIRMAGÜL B., Oner S., Erol K.

Pain Clinic, vol.18, no.1, pp.57-62, 2006 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1163/156856906775249893
  • Journal Name: Pain Clinic
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.57-62
  • Eskisehir Osmangazi University Affiliated: Yes


Alpha-tocopherol is an antioxidant which has been suggested to have anti-inflammatory and analgesic activities in humans. However, the anti-inflamatory and analgesic effetcs of alpha-tocopherol in mice had not been studied. Therefore, this study was designed to determine the antinociceptive doses of alpha-tocopherol in mice. In addition, this study aims to compare the activity of alpha-tocopherol with those of dipyrone and aspirin and to investigate the role of nitric oxide (NO) in the antinociceptive activity of alpha-tocopherol in mice. Hot plate, tail clip and tail flick tests were applied to evaluate the central antinociceptive activity using 1, 5, 25 and 100 mg/kg intraperitoneal doses of alpha-tocopherol. A dose-dependent antinociceptive activity was observed at low doses, the most effective dose was 25 mg/kg. Furthermore, it was observed that co-administration of L-arginine (100 mg/kg) with alpha-tocopherol (25 mg/kg) reduced the antinociceptive activity and this activity was compared with those of dipyrone and aspirin. These results showed that alpha-tocopherol has central antinociceptive activity and that NO may play a role on its effect. © 2006 VSP.