A study of the possible association of plasminogen activator inhibitor type 1 4G/5G insertion/deletion polymorphism with susceptibility to schizophrenia and in its subtypes
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, cilt.42, sa.1, ss.103-107, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 1
- Basım Tarihi: 2017
- Doi Numarası: 10.1111/jcpt.12470
- Dergi Adı: JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.103-107
- Anahtar Kelimeler: PAI-1 4G, 5G polymorphism, schizophrenia, MAJOR DEPRESSION, GENE PROMOTER, PAI-1, THROMBOSIS, FIBRINOLYSIS, GENOTYPE, SYSTEM, ACE
- Eskişehir Osmangazi Üniversitesi Adresli: Evet
Özet
What is known and objectiveInhibition of the fibrinolytic system may occur at the level of plasminogen activation, mainly by PAI-1. Mental and physical stress caused to alterations of platelet function, and also decreased to fibrinolytic activity. Furthermore, stress-induced thrombosis regulation was proposed to be by PAI-1 in schizophrenia patients. In this study, the distribution of genotypes and frequency of alleles of the plasminogen activator inhibitor type 1 (PAI-1) gene 4G/5G polymorphism in different Turkish clinical schizophrenia subtypes was investigated for its role in schizophrenia development.