Clinical significance of serum IL-6, TNF-alpha, Hepcidin, and EPO levels in anaemia of chronic disease and iron deficiency anaemia: The laboratory indicators for anaemia

ÜSKÜDAR TEKE H., ÜSKÜDAR CANSU D., YILDIZ P., Temiz G., BAL C.

BIOMEDICAL RESEARCH-INDIA, cilt.28, sa.6, ss.2704-2710, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 6
  • Basım Tarihi: 2017
  • Dergi Adı: BIOMEDICAL RESEARCH-INDIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core
  • Sayfa Sayıları: ss.2704-2710
  • Anahtar Kelimeler: Anemia, Chronic disease, Cytokine, CHRONIC KIDNEY-DISEASE, RHEUMATOID-ARTHRITIS, TRANSFERRIN RECEPTOR, RENAL-DISEASE, ERYTHROPOIETIN, INFLAMMATION, HEMODIALYSIS, PROTEIN, PEPTIDE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background: Pathogenesis of anaemia of chronic disease is multifactorial. It is related with corrupted erythropoietin-dependent erythropoiesis due to C-reactive protein, and pro-inflammatory cytokines, such as interleukin-6 and tumor necrosis factor-alpha. It is also related with decreased red cell survival and impaired iron mobilization. Hepcidin level in iron deficiency anaemia is low than controls but it is high in patients with chronic renal failure. Pro-inflammatory cytokines are associated with the pathogenesis of rheumatoid arthritis and development of anaemia in rheumatoid arthritis.