Effect of denervation and ischemia reperfusion injury on serum nitric oxide levels in rats
Saudi Medical Journal, cilt.29, sa.11, ss.1561-1566, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 11
- Basım Tarihi: 2008
- Dergi Adı: Saudi Medical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1561-1566
- Eskişehir Osmangazi Üniversitesi Adresli: Hayır
Özet
Objectives: To evaluate the effect of renal denervation and serum nitric oxide level with a different time course of renal ischemia-reperfusion injury. Methods: Thirty-six male. Wistar rats were randomized into 6 groups. All rats underwent right nephrectomy to create a single kidney model. Renal denervated and innerved rats were subjected to renal clamping for 30-60 minutes. The study was performed in the Department of Anatomy, Akdeniz University, Antalya, Turkey, between June and November 2005. Results: Combined effect of denervation and ischemia may caused significant increase in serum nitric oxide levels and decrease in glomerular filtration rates. Conclusion: Our results indicate that kidney denervation did not cause any changes in renal functions, but with ischemia it worsens the deleterious effect of ischemia-reperfusion injury, and causes a significant increase in serum nitric oxide levels.