An antibacterial composite system based on multi-responsive microgels hosting monodisperse gold nanoparticles

Ulker D., TUNCER C., Sezgin S. B., Toptas Y., ÇABUK A., BÜTÜN V.

JOURNAL OF POLYMER RESEARCH, vol.24, no.10, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 10
  • Publication Date: 2017
  • Doi Number: 10.1007/s10965-017-1336-y
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Microgels, Metal nanoparticles, Composites, Catalytic effect, Antibacterial, Responsive systems, GRAM-NEGATIVE BACTERIA, MAGNETIC NANOPARTICLES, SILVER NANOPARTICLES, CATALYTIC-REDUCTION, POLYMER MICROGELS, METAL, PARTICLES, MODEL, PH
  • Eskisehir Osmangazi University Affiliated: Yes


A multi-responsive microgel having response to pH, temperature, and salt concentration was successfully prepared using a water-soluble monomer. Microgels were readily prepared from 2-(N-morpholino) ethyl methacrylate (MEMA) via emulsion polymerization using glycidyl methacrylate as a comonomer cross-linker. The morpholino groups of MEMA residues of microgels were able to give complexation with metal containing anions such as AuCl4- in acidic conditions. The reduction of aurate ions with sodium borohydride led to immobilized-gold nanoparticles (AuNP) in the microgel system. Average particle diameters of AuNPs were determined to be 10 +/- 2 nm. The resulting AuNP-microgel system was examined as a nanoreactor for catalyst system and determined to be very effective in the reduction of 4-nitrophenol model reaction in aqueous media. AuNPs-microgel composite system had antibacterial properties against several Gram-positive and Gram-negative bacteria similar to amoxicillin. This P(MEMA-co-GMA) microgel is also very useful for different applications such as a host for metal nanoparticle production, a drug carrier or drug delivery system.