An antibacterial composite system based on multi-responsive microgels hosting monodisperse gold nanoparticles

Ulker D., TUNCER C. , Sezgin S. B. , Toptas Y., ÇABUK A. , BÜTÜN V.

JOURNAL OF POLYMER RESEARCH, cilt.24, sa.10, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Konu: 10
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s10965-017-1336-y


A multi-responsive microgel having response to pH, temperature, and salt concentration was successfully prepared using a water-soluble monomer. Microgels were readily prepared from 2-(N-morpholino) ethyl methacrylate (MEMA) via emulsion polymerization using glycidyl methacrylate as a comonomer cross-linker. The morpholino groups of MEMA residues of microgels were able to give complexation with metal containing anions such as AuCl4- in acidic conditions. The reduction of aurate ions with sodium borohydride led to immobilized-gold nanoparticles (AuNP) in the microgel system. Average particle diameters of AuNPs were determined to be 10 +/- 2 nm. The resulting AuNP-microgel system was examined as a nanoreactor for catalyst system and determined to be very effective in the reduction of 4-nitrophenol model reaction in aqueous media. AuNPs-microgel composite system had antibacterial properties against several Gram-positive and Gram-negative bacteria similar to amoxicillin. This P(MEMA-co-GMA) microgel is also very useful for different applications such as a host for metal nanoparticle production, a drug carrier or drug delivery system.