Neuroprotective Effect of Resveratrol on Acute Brain Ischemia Reperfusion Injury by Measuring Annexin V, p53, Bcl-2 Levels in Rats

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Kizmazoglu C., Aydin H. E., Sevin I. E., KALEMCİ O., Yuceer N., Atasoy M. A.

JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, vol.58, no.6, pp.508-512, 2015 (SCI-Expanded) identifier identifier identifier


Background : Cerebral ischemia is as a result of insufficient cerebral blood flow for cerebral metabolic functions. Resveratrol is a natural phytoalexin that can be extracted from grape's skin and had potent role in treating the cerebral ischemia. Apoptosis, a genetically programmed cellular event which occurs after ischemia and leads to biochemical and morphological changes in cells. There are some useful markers for apoptosis like Bcl-2, bax, and p53. The last reports, researchers verify the apoptosis with early markers like Annexin V.