Neuroprotective Effect of Resveratrol on Acute Brain Ischemia Reperfusion Injury by Measuring Annexin V, p53, Bcl-2 Levels in Rats

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Kizmazoglu C., Aydin H. E., Sevin I. E., KALEMCİ O., Yuceer N., Atasoy M. A.

JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, cilt.58, sa.6, ss.508-512, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3340/jkns.2015.58.6.508
  • Dergi Adı: JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.508-512
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Background : Cerebral ischemia is as a result of insufficient cerebral blood flow for cerebral metabolic functions. Resveratrol is a natural phytoalexin that can be extracted from grape's skin and had potent role in treating the cerebral ischemia. Apoptosis, a genetically programmed cellular event which occurs after ischemia and leads to biochemical and morphological changes in cells. There are some useful markers for apoptosis like Bcl-2, bax, and p53. The last reports, researchers verify the apoptosis with early markers like Annexin V.