The effect of methylprednisolone treatment on cerebral reactivity in patients with multiple sclerosis

Ozkan S., Uzuner N., Kutlu C., Ozbabalik D., Ozdemir G.

JOURNAL OF CLINICAL NEUROSCIENCE, cilt.13, sa.2, ss.214-217, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.jocn.2005.03.023
  • Dergi Adı: JOURNAL OF CLINICAL NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.214-217
  • Anahtar Kelimeler: multiple sclerosis, cerebral reactivity, transcranial Doppler, methylprednisolone, POSITRON-EMISSION-TOMOGRAPHY, BLOOD-FLOW RESPONSE, INJURY, SHOWS, EDSS, MRI
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

We assessed the effect of intravenous high-dose methylprednisolone (IVMP) on cerebral reactivity in multiple sclerosis (MS) patients during exacerbations by means of functional transcranial Doppler imaging. Forty-eight clinically defined MS patients were evaluated with visual evoked potentials (VEP) and functional transcranial Doppler sonography (TCD) of both posterior cerebral arteries before and after 5 days of 1000 mg IVMP. After treatment, mean Expanded Disability Status Scale score, mean blood flow velocities and mean blood flow velocities at rest and at stimulation, significantly decreased (p < 0.0001, for each). The change in cerebral blood flow velocity ratio (CBFv) with visual stimulation after treatment increased slightly (p = 0.20). All TCD parameters were not significantly correlated with VEP changes. In conclusion, we observed significant changes in CBFv with a non-significant increase in vascular reactivity after treatment with IVMP in exacerbations of MS. Case-control studies are necessary to draw conclusions regarding the beneficial effects of IVMP treatment. (c) 2005 Elsevier Ltd. All rights reserved.