7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis

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KORKMAZ O. T., Aytan N., Carreras I., Choi J., Kowall N. W., Jenkins B. G., ...Daha Fazla

NEUROSCIENCE LETTERS, cilt.566, ss.286-291, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 566
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.neulet.2014.02.058
  • Dergi Adı: NEUROSCIENCE LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.286-291
  • Anahtar Kelimeler: Amyotrophic lateral sclerosis, 7,8-Dihydroxyflavone, Motor neurons, BDNF, TrkB, TRKB RECEPTOR, NEUROTROPHIC FACTORS, SYNAPTIC PLASTICITY, BDNF, AGONIST, MEMORY, POTENTIATION, MOTONEURONS, SYNAPSES, SPINES
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Amyotrophic lateral sclerosis (ALS) is an enigmatic neurodegenerative disorder without any effective treatment characterized by loss of motor neurons (MNs) that results in rapidly progressive motor weakness and early death due to respiratory failure. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family known to play a prominent role in the differentiation and survival of MNs. The flavonoid 7,8-dihydroxyflavone (7,8-DHF) is a potent and selective small molecule tyrosine kinase receptor B (TrkB) agonist that mimics the effects of BDNF. In the present study, we evaluated the neuroprotective effects of 7,8-DHF in a transgenic ALS mouse model (SOD1(G93A)). We found that chronic administration of 7,8-DHF significantly improved motor deficits, and preserved spinal MNs count and dendritic spines in SOD1(G93A) mice. These data suggest that 7,8-DHF should be considered as a potential therapy for ALS and the other motor neuron diseases. Published by Elsevier Ireland Ltd.