Evaluation of cardiovascular risk in children with solitary functioning kidney
CLINICAL AND EXPERIMENTAL NEPHROLOGY, cilt.26, sa.5, ss.415-423, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 5
- Basım Tarihi: 2022
- Doi Numarası: 10.1007/s10157-021-02169-7
- Dergi Adı: CLINICAL AND EXPERIMENTAL NEPHROLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
- Sayfa Sayıları: ss.415-423
- Anahtar Kelimeler: Solitary kidney, Cardiovascular risk, Children, Carotid intima-media thickness, Ischemia-modified albumin, 24-h ambulatory blood pressure monitoring, ISCHEMIA-MODIFIED ALBUMIN, BLOOD-PRESSURE, MYOCARDIAL-ISCHEMIA, OXIDATIVE STRESS, HEART-FAILURE, DISEASE, BINDING, MARKER, ASSAY, PROTEINURIA
- Eskişehir Osmangazi Üniversitesi Adresli: Evet
Özet
Background The present study investigates cardiovascular risk and kidney damage in patients with solitary kidneys. Methods Included in the study were 40 children with a unilateral functioning kidney and 60 healthy controls, all of whom were evaluated for carotid intima-media thickness, ischemia-modified albumin and oxidative stress parameters, and 24-h ambulatory blood pressure monitoring. Results Serum creatinine and urine microalbumin levels were higher and creatinine clearance was lower in the patient group than in the control group, and serum ischemia-modified albumin, carotid intima-media thickness, aldosterone, plasma renin activity and blood pressure were all higher in the patient group than in the control group. In addition, the patient group was showed a non-dipper pattern. Conclusion Children with a normal functioning solitary kidney are likely at higher risk of developing cardiovascular disease and such patients should be followed closely before marked kidney impairment occurs.