Structural, optical, and gamma radiation safety properties of 46V(2)O(5)center dot 46P(2)O(5)center dot(8-x)B2O3 center dot xZnO (x = 0,2,4,6, and 8 mol%) abbreviated as VPB/Zn glasses were investigated. The structure of the synthesized glasses has been examined via FTIR spectra within the range of 400-1500 cm(-1) at room temperature. UV-Vis-NIR measurements of the proposed glasses were performed within the range of 200-3300 nm. The optical characteristics such as optical energy bandgap (EOptica), refractive index (n(Linear)), and Urbach's energy (E-U) have been determined. In addition, the mass attenuation coefficients (MAC) for VPB/Zn glasses were performed utilizing MCNP-5 simulation code and XCOM program for various gamma ray energy varied in range 0.015-15 MeV. Based on MAC values, the equivalent atomic number (Z(eq)) and buildup factors (EABF and EBF) were evaluated. Results reveal that the direct EOpticalTauc ' s of the VPB/Zn glasses ranged from 0.688 to 0.710 eV, while from 0.560 to 0.647 eV for the indirect transition. The admission of the ZnO improves the MAC of the VPB/Zn glasses. Thus, one can conclude that the proposed glasses can be applied for optical devices as semiconductor glasses and considered as good materials for gamma-rays shielding.