Oxidant and antioxidant status in neonatal proven and clinical sepsis according to selenium status

Asci A., Surmeli-Onay Ö., Erkekoglu P., YİĞİT Ş., YURDAKÖK M., Kocer-Gumusel B.

PEDIATRICS INTERNATIONAL, vol.57, no.6, pp.1131-1137, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.1111/ped.12698
  • Journal Name: PEDIATRICS INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1131-1137
  • Keywords: antioxidant enzyme, clinical sepsis, oxidative stress, proven sepsis, selenium, selenoenzyme, SYSTEMIC INFLAMMATORY RESPONSE, SEPTIC SHOCK, GLUTATHIONE-PEROXIDASE, LIPID-PEROXIDATION, OXIDATIVE STRESS, PLASMA, THIOREDOXIN, MORTALITY
  • Eskisehir Osmangazi University Affiliated: No

Abstract

BackgroundSelenium is a trace element required for the functioning of the immune system. Neonatal sepsis is a serious condition leading to morbidity and mortality in neonates worldwide. The purpose of this study was to measure selenium and plasma selenoprotein P (SePP), selenoenzyme activity, and alterations in oxidant/antioxidant status with immune biomarkers in neonates with clinical (n=27) and proven neonatal sepsis (n=25).