The Prevalence of Gap Junction Protein Beta 2 (GJB2) Mutations in Non Syndromic Sensorineural Hearing Loss in Cukurova Region

Bozdogan S. T., Kuran G., Yuregir O. O., Aslan H., Haytoglu S., Ayaz A., ...More

JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, vol.11, no.2, pp.118-121, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.5152/iao.2015.1212
  • Journal Name: JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.118-121
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

OBJECTIVE: To date, studies in all populations showed that mutations in the gene of Gap junction protein beta 2 (GJB2) play an important role in non-syndromic autosomal recessive congenital hearing loss. The aim of this study was to evaluate GJB2 gene of patients with hearing loss in our region using deoxyribonucleic acid (DNA) sequencing method and to demonstrate region-specific mutation and polymorphism distribution.