New Benzodioxole-based Pyrazoline Derivatives: Synthesis and Anticandidal, In silico ADME, Molecular Docking Studies


ÖZDEMİR A., SEVER B., ALTINTOP M. D.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.16, no.1, pp.82-92, 2019 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.2174/1570180815666180326152726
  • Title of Journal : LETTERS IN DRUG DESIGN & DISCOVERY
  • Page Numbers: pp.82-92

Abstract

Background: Azoles are commonly used in the treatment and prevention of fungal infections. They suppress fungal growth by acting on the heme group of lanosterol 14 alpha-demethylase enzyme (CYP51), thus blocking the biosynthesis of ergosterol.