Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension

Donertas Ayaz B., Oliveira A. C., Malphurs W. L., Redler T., De Araujo A. M., Sharma R. K., ...Daha Fazla

Frontiers in Neuroscience, cilt.15, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3389/fnins.2021.690919
  • Dergi Adı: Frontiers in Neuroscience
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Directory of Open Access Journals
  • Anahtar Kelimeler: hydrogen sulfide, hypertension, microglia, neuroinflammation, paraventricular nucleus, microbiota, angiotensin, HEART-RATE-VARIABILITY, AUTONOMIC NERVOUS-SYSTEM, PARAVENTRICULAR NUCLEUS, BLOOD-PRESSURE, NITRIC-OXIDE, GUT MICROBIOTA, BONE-MARROW, ENDOTHELIAL DYSFUNCTION, ARTERIAL-PRESSURE, OXIDATIVE STRESS
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

© Copyright © 2021 Donertas Ayaz, Oliveira, Malphurs, Redler, de Araujo, Sharma, Sirmagul and Zubcevic.Hydrogen sulfide (H2S) is a gaseous signaling molecule with neuromodulatory, anti-inflammatory, and anti-hypertensive effects. Here, we investigate whether chronic intracerebroventricular (ICV) infusion of sodium hydrosulfide (NaHS), an H2S donor, can alleviate angiotensin II (Ang II)–induced hypertension (HTN), improve autonomic function, and impact microglia in the paraventricular nucleus (PVN) of the hypothalamus, a brain region associated with autonomic control of blood pressure (BP) and neuroinflammation in HTN. Chronic delivery of Ang II (200 ng/kg/min, subcutaneous) for 4 weeks produced a typical increase in BP and sympathetic drive and elevated the number of ionized calcium binding adaptor molecule 1–positive (Iba1+) cells in the PVN of male, Sprague–Dawley rats. ICV co-infusion of NaHS (at 30 and/or 60 nmol/h) significantly attenuated these effects of Ang II. Ang II also increased the abundance of cecal Deltaproteobacteria and Desulfovibrionales, among others, which was prevented by ICV NaHS co-infusion at 30 and 60 nmol/h. We observed no differences in circulating H2S between the groups. Our results suggest that central H2S may alleviate rodent HTN independently from circulating H2S via effects on autonomic nervous system and PVN microglia.