Preparation of Responsive Zwitterionic Diblock Copolymers Containing Phosphate and Phosphonate Groups

Samav Y., Akpinar B., KOÇAK G., BÜTÜN V.

MACROMOLECULAR RESEARCH, cilt.28, sa.12, ss.1134-1141, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 12
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s13233-020-8148-3
  • Dergi Adı: MACROMOLECULAR RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Compendex, INSPEC
  • Sayfa Sayıları: ss.1134-1141
  • Anahtar Kelimeler: pH-responsive polymer, temperature-responsive polymer, zwitterionic polymers, phosphorus-based polymers, micelles, self-assembly, nanoparticles, diblock copolymer, CROSS-LINKED MICELLES, BLOCK-COPOLYMERS, RAFT COPOLYMERIZATION, POLYMERIZATION, ACID, POLYMERS, METHACRYLATE, CHAIN, STABILIZATION, OPPORTUNITY
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

In this study, novel zwitterionic diblock copolymers, namely poly(2-(N-morpholino)ethyl methacrylate))-block-poly(2-(methacryloyloxy)ethyl phosphate) (PMEMA-b-PMOEP) and poly(2-(N-morpholino)ethyl methacrylate))-block-poly ((methacryloyloxy)methyl phosphonic acid) (PMEMA-b-PMOMP), were synthesizedviareversible addition-fragmentation chain transfer controlled radical polymerization. Solution properties of these phosphorus-based diblock copolymers were investigated using dynamic light scattering, transmission electron microscopy and proton nuclear magnetic resonance spectroscopy. Since the PMEMA block has both salt- and thermo-responsive properties, PMEMA-b-PMOEP and PMEMA-b-PMOMP diblock copolymers formed core-shell micelles in basic aqueous media as the PMEMA block formed insoluble micelle core with the addition of Na2SO4 or an increase in temperature in basic solution. Additionally, PMEMA-b-PMOMP diblock copolymers interacted strongly with calcium cations and yielded reverse micellar structures via complexation of phosphate with metal cation in aqueous media.