Akademik Veri Yönetim Sistemi
SAKARYA UNIVERSITY JOURNAL OF SCIENCE, cilt.26, sa.1, ss.120-127, 2022 (Hakemli Dergi)
Microfluidic chip systems have been an area of interest for lab-on-a-chip and organ-on-a-chip
studies in recent years. These chips have many advantages such as high efficiency, low sample
consumption, fast analysis, durability and low cost. Today, electrochemical sensors are
frequently applied in microfluidic chips because of their potential for label-free detection and
low-cost production. A commonly employed electrochemical technique is electrochemical
impedance spectroscopy (EIS), which captures changes in phase and amplitude as signal passes
through the system under test. In the utilization of microelectrodes within microfluidic
channels, noise becomes a problem in EIS measurements. In this study, EIS measurements were
performed using microfluidic chips with various dimensions of width while the properties and
dimensions of the microelectrodes were kept constant. It was found that the results of cyclic
voltammetry (CV) cleaning and EIS experiments deteriorated when smaller than 1 mm widemicrochannels were integrated onto 100 µm wide microelectrodes. These finding sets the basics
for on-chip electrochemistry experiments using microfluidic integrated microelectrodes and
therefore is fundamentally important in future on-chip EIS measurements.