Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives

TAY N. F., DURAN M., Kayagil I., Yurttas L., GÖGER G., Goger F., ...More

BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol.58, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 58
  • Publication Date: 2022
  • Doi Number: 10.1590/s2175-97902022e191026
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: Triazole, Thiazole, Pyridine, Antimicrobial activity, Antioxidant activity, DPPH radical scavenging, 1,2,4-TRIAZOLE DERIVATIVES, BIOLOGICAL EVALUATION, IN-VITRO, MOLECULAR DOCKING, HYBRID MOLECULES, LINKED BIS, ANTIFUNGAL, ANTITUMOR, ANTIBACTERIAL, AGENTS
  • Eskisehir Osmangazi University Affiliated: Yes


In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 mu g/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity.