Frequency of genetic polymorphism for adrenergic receptor beta and cytochrome p450 2D6 enzyme, and effects on tolerability of beta-blocker therapy in heart failure with reduced ejection fraction patients: The Beta GenTURK study

ZOGHİ, MEHDİ; KAYA, HAKKI; ÇAVUŞOĞLU, YÜKSEL; AKSAKAL, Enbiya; Demir, Serafettin; Yucel, Ceyhun; Mutlu, Hasim; Ergene, Oktay; YILMAZ, MEHMET

doi:10.5543/tkda.2016.10733

Frequency of genetic polymorphism for adrenergic receptor beta and cytochrome p450 2D6 enzyme, and effects on tolerability of beta-blocker therapy in heart failure with reduced ejection fraction patients: The Beta GenTURK study

ZOGHİ M., KAYA H., ÇAVUŞOĞLU Y., AKSAKAL E., Demir S., Yucel C., ...Daha Fazla

TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY, cilt.44, sa.6, ss.457-465, 2016 (ESCI, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 44 Sayı: 6
Basım Tarihi: 2016
Doi Numarası: 10.5543/tkda.2016.10733
Dergi Adı: TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.457-465
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective: The present objective was to determine frequency of Arginine389Glycine (Arg389Gly) and Cytochrome p450 2D6*10 (Cyp2D6*10) polymorphism in cases of heart failure-reduced ejection fraction (HFREF), and to evaluate the influence of the polymorphisms in response to beta-blocker (BB) therapy.