Objective: Curcumin is a bioactive compound that has well-known pharmacological activities. Numerous studies have shown that curcumin provides potential cardiovascular benefits through a variety of mechanisms.The present study aims to discuss different concentrations of curcum- in’s impact on mechanical functions and cardiac contractility in isolated perfused rat hearts. Methods: The hearts were isolated under sodium thiopental (50 mg/kg) anesthesia and per- fused with a modified Krebs-Henseleit solution (mK-Hs). After stabilization, curcumin was applied in concentrations of 0.1, 1, and 10 μM. In isolated rat hearts, indexes of + dP / dt max, LVDP, MAP, and LVEDP were evaluated for cardiac contractility and ventricular function. Results: All curcumin concentrations reduced +dP/dtmax and LVDP. Ten μM curcumin also sig- nificantly decreased heart rate. Curcumin (1 and 10 μM) increased LVEDP and reduced MAP amplitude with a concomitant increase in MAP duration. Curcumin at all concentrations did not affect dMAPdtmax and dMAPdtmin. Conclusion: Our results might suggest that curcumin at higher concentrations (≥ 1 μM) increases LVEDP with a negative chronotropic effect and decreases MAP amplitude with an increase in MAP duration. There is sufficient evidence from this study that Curcumin possesses an adverse inotropic action. Different disease models should support the pathophysiological role of Curcumin on cardiac contraction.