Impact of cytoreductive surgery on survival of patients with low-grade serous ovarian carcinoma: A multicentric study of Turkish Society of Gynecologic Oncology (TRSGO-OvCa-001)

Vatansever D., Taskiran C., Mutlu Meydanli M., Gungorduk K., Akbayir O., Yalcin I., ...Daha Fazla

Journal of Surgical Oncology, cilt.123, sa.8, ss.1801-1810, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 123 Sayı: 8
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/jso.26450
  • Dergi Adı: Journal of Surgical Oncology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1801-1810
  • Anahtar Kelimeler: cytoreductive surgery, endometriosis, low grade serous ovarian cancer, lymphovascular space invasion, LYMPHOVASCULAR SPACE INVASION, WOMEN, CANCER, CHEMOTHERAPY, PERITONEUM, MUTATIONS, PATTERNS, DISEASE, BRAF
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

© 2021 Wiley Periodicals LLCBackground and Objectives: The aim of this study was to analyze the factors affecting recurrence-free (RFS) and overall survival (OS) rates of women diagnosed with low-grade serous ovarian cancer (LGSOC). Methods: Databases from 13 participating centers in Turkey were searched retrospectively for women who had been treated for stage I–IV LGSOC between 1997 and 2018. Results: Overall 191 eligible women were included. The median age at diagnosis was 49 years (range, 21–84 years). One hundred seventy-five (92%) patients underwent primary cytoreductive surgery. Complete and optimal cytoreduction was achieved in 148 (77.5%) and 33 (17.3%) patients, respectively. The median follow-up period was 44 months (range, 2–208 months). Multivariate analysis showed the presence of endometriosis (p =.012), lymphovascular space invasion (LVSI) (p =.022), any residual disease (p =.023), and the International Federation of Gynecology and Obstetrics (FIGO) stage II–IV disease (p =.045) were negatively correlated with RFS while the only presence of residual disease (p =.002) and FIGO stage II–IV disease (p =.003) significantly decreased OS. Conclusions: The maximal surgical effort is warranted for complete cytoreduction as achieving no residual disease is the single most important variable affecting the survival of patients with LGSOC. The prognostic role of LVSI and endometriosis should be evaluated by further studies as both of these parameters significantly affected RFS.