Antimicrobial compounds from Pimpinella species growing in Turkey


Tabanca N., Bedir E., Kirimer N., Baser K., Khan S., Jacob M., ...Daha Fazla

PLANTA MEDICA, cilt.69, sa.10, ss.933-938, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Konu: 10
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1055/s-2003-45103
  • Dergi Adı: PLANTA MEDICA
  • Sayfa Sayıları: ss.933-938

Özet

A new, 4-(2-propenyl)-phenyl angelate (1) and four known phenylpropanoids (2-5), were isolated from Pimpinella isaurica, a species endemic in Turkey. One new sesquiterpene, 1-methyl-4-(5-methyl-1-methylenehex-4-enyl)-7-oxabicyclo[4.1.0]heptane (6) was obtained from P. aurea and two known phenylpropanoids were isolated (7, 8), from P. corymbosa. The structure elucidation of the new compounds 1 and 6 was achieved by a combination of one- (H-1, and C-13) and two-dimensional NMR techniques (G-DQF-COSY, G-HMQC, and G-HMBC, and LC-ESI-FTMS. Compounds 1, 2, 4, 6, 7, 8 have been evaluated for their antimalarial and antimicrobial activities. Compound 1, 2, 4, 6, 8 had antimicrobial activity against Mycobacterium intracellulare with IC50 values of 7.0,15.0, 2.5, 10.0 and 1.5 mug/mL, respectively.