Antimicrobial compounds from Pimpinella species growing in Turkey

Tabanca N., Bedir E., Kirimer N., Baser K., Khan S., Jacob M., ...More

PLANTA MEDICA, vol.69, no.10, pp.933-938, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 10
  • Publication Date: 2003
  • Doi Number: 10.1055/s-2003-45103
  • Journal Name: PLANTA MEDICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.933-938
  • Eskisehir Osmangazi University Affiliated: No

Abstract

A new, 4-(2-propenyl)-phenyl angelate (1) and four known phenylpropanoids (2-5), were isolated from Pimpinella isaurica, a species endemic in Turkey. One new sesquiterpene, 1-methyl-4-(5-methyl-1-methylenehex-4-enyl)-7-oxabicyclo[4.1.0]heptane (6) was obtained from P. aurea and two known phenylpropanoids were isolated (7, 8), from P. corymbosa. The structure elucidation of the new compounds 1 and 6 was achieved by a combination of one- (H-1, and C-13) and two-dimensional NMR techniques (G-DQF-COSY, G-HMQC, and G-HMBC, and LC-ESI-FTMS. Compounds 1, 2, 4, 6, 7, 8 have been evaluated for their antimalarial and antimicrobial activities. Compound 1, 2, 4, 6, 8 had antimicrobial activity against Mycobacterium intracellulare with IC50 values of 7.0,15.0, 2.5, 10.0 and 1.5 mug/mL, respectively.