Akademik Veri Yönetim Sistemi
FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI, cilt.28, ss.225-237, 2023 (ESCI)
Introduction: Developing and changing medical practices may cause a change in the frequency, variety and susceptibility of infection agents over years. Therefore, the analysis reports of the isolates in urinary tract infections (UTIs) will provide significant contributions to the correct management of these infections. We aimed to analyze the trends of frequency, distribution and antimicrobial susceptibility of agents isolated from urine cultures of both ambulatory patients and inpatients in this study. Materials and Methods: We evaluated the results of urine cultures for a 14-year period, retrospectively. Results: A total of 49.034 isolates from 46.626 culture positive nonrepetitive specimens were included. The most common isolate was E. coli (46.2%), followed by Enterococcus species (12.2%). Significant differences in species distribution were observed based on gender and the units where patients were treated, including ambulatory care, inpatient units, and intensive care units. The highest susceptibility rates for E. coli were observed with imipenem (& GE;99%) and amikacin (& GE;86%). The susceptibility of E. coli to cefazolin decreased over the years (from 70% to 32%). Enterococcus spp. were susceptible to vancomycin and linezolid with high rates (& GE;92% and & GE;95%, respectively). A prominent decrease was observed in the susceptibility rate for Enterococcus spp. against ampicillin in years; from 94% to 68%. A continuous decreasing trend was detected in the susceptibility of Klebsiella spp. Conclusion: E. coli continues to be the most common urinary isolate. The distribution and frequency of isolates may show difference among centers and units. Continuous monitoring of antimicrobial susceptibility is important for accurate management of UTIs.