L-Carnitine Treatment In Acute Valproic Acid Intoxication: Case Report

Ozer D., Yildirim V., Ayyildiz A., Karakoc E., YELKEN B.

JOURNAL OF MEDICAL AND SURGICAL INTENSIVE CARE MEDICINE, cilt.10, sa.3, ss.96-98, 2019 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.33381/dcbybd.2019.2037
  • Dergi Adı: JOURNAL OF MEDICAL AND SURGICAL INTENSIVE CARE MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.96-98
  • Anahtar Kelimeler: valproic acid, L-carnitine, hemodialysis, drug abuse, OVERDOSE, HEMOPERFUSION, HEMODIALYSIS, TOXICITY, SERIES
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Valproic acid (VPA) is a widely used drug with various indications (psychiatric disorders, epilepsy, migraine etc.) and it has been used in many cases of suicide attempts. VPA intoxication may cause electrolyte imbalances, hepatotoxicity, pancreatitis, bone marrow suppression, and brain edema. The most common finding in VPA intoxication is coma and respiratory depression as a result of central nervous system suppression. Case reports emphasize that the efficacy of L-carnitine and various extracorporeal elimination techniques like intermittent hemodialysis or continuous renal replacement therapies in the treatment of VPA intoxication. In this report we present the case of a 34 year old female with VPA intoxication who was successfully treated with L-carnitine.