Relationship between serum bilirubin levels and presence of fragmented QRS in patients with acute coronary syndrome

Dural M., Sunman H., Algul E., Hocamguliyev H., Sahan H. F., Cimen T., ...Daha Fazla

BIOMARKERS IN MEDICINE, cilt.14, sa.1, ss.65-73, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2217/bmm-2018-0493
  • Dergi Adı: BIOMARKERS IN MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.65-73
  • Anahtar Kelimeler: acute coronary syndrome, bilirubin, electrocardiography, fragmented QRS, heme, inflammation, long-term follow-up, percutaneous coronary intervention, ST segment, troponin, ACUTE MYOCARDIAL-INFARCTION, IN-HOSPITAL MACE, 12-LEAD ECG, COMPLEX, INTERVENTION, ANTIOXIDANT, BILIVERDIN, MORTALITY, PROTECTS, SUBTYPES
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Aim: To assess the relationship between serum bilirubin levels and fragmented QRS (fQRS), and their association with adverse events in patients with acute coronary syndrome. Methods: This study included a total of 736 patients. Laboratory results such as bilirubin levels, renal and liver function tests were obtained from the first available blood sample. Results: Left ventricular ejection fraction, end-diastolic diameter and total bilirubin level were significantly lower in fQRS (+) group than in the control group (45.0 [40.0-55.0] vs 50.0 [45.0-60.0]%; p < 0.001; 4.7 [4.6-5.1] vs 4.7 [4.5-4.9] cm; p < 0.001; 0.66 [0.49-5.1] vs 0.72 [0.53-0.97] md/dl; p = 0.017); respectively. Occurrence of adverse events was significantly higher in fQRS (+) group (32.5 vs 20.5 %; p = 0.013) during mean 1-year follow-up period. Conclusion: Total bilirubin level is an independent predictor of fQRS formation, which is associated with the presence of adverse events in patients with acute coronary syndrome.