Relationship between serum bilirubin levels and presence of fragmented QRS in patients with acute coronary syndrome

Dural M., Sunman H., Algul E., Hocamguliyev H., Sahan H. F., Cimen T., ...More

BIOMARKERS IN MEDICINE, vol.14, no.1, pp.65-73, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.2217/bmm-2018-0493
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.65-73
  • Keywords: acute coronary syndrome, bilirubin, electrocardiography, fragmented QRS, heme, inflammation, long-term follow-up, percutaneous coronary intervention, ST segment, troponin, ACUTE MYOCARDIAL-INFARCTION, IN-HOSPITAL MACE, 12-LEAD ECG, COMPLEX, INTERVENTION, ANTIOXIDANT, BILIVERDIN, MORTALITY, PROTECTS, SUBTYPES
  • Eskisehir Osmangazi University Affiliated: Yes


Aim: To assess the relationship between serum bilirubin levels and fragmented QRS (fQRS), and their association with adverse events in patients with acute coronary syndrome. Methods: This study included a total of 736 patients. Laboratory results such as bilirubin levels, renal and liver function tests were obtained from the first available blood sample. Results: Left ventricular ejection fraction, end-diastolic diameter and total bilirubin level were significantly lower in fQRS (+) group than in the control group (45.0 [40.0-55.0] vs 50.0 [45.0-60.0]%; p < 0.001; 4.7 [4.6-5.1] vs 4.7 [4.5-4.9] cm; p < 0.001; 0.66 [0.49-5.1] vs 0.72 [0.53-0.97] md/dl; p = 0.017); respectively. Occurrence of adverse events was significantly higher in fQRS (+) group (32.5 vs 20.5 %; p = 0.013) during mean 1-year follow-up period. Conclusion: Total bilirubin level is an independent predictor of fQRS formation, which is associated with the presence of adverse events in patients with acute coronary syndrome.