The protective effect of vasoactive intestinal peptide (VIP) on stress-induced gastric ulceration in rats

Tuncel, N; Erkasap, NİLÜFER; ŞAHİNTÜRK, VAROL; Dogrukolak, D; Tuncel, M

doi:10.1111/j.1749-6632.1998.tb11191.x

The protective effect of vasoactive intestinal peptide (VIP) on stress-induced gastric ulceration in rats

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Tuncel N., Erkasap N., ŞAHİNTÜRK V., Dogrukolak D., Tuncel M.

VIP, PACAP, AND RELATED PEPTIDES, vol.865, pp.309-322, 1998 (SCI-Expanded)

Publication Type: Article / Article
Volume: 865
Publication Date: 1998
Doi Number: 10.1111/j.1749-6632.1998.tb11191.x
Journal Name: VIP, PACAP, AND RELATED PEPTIDES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.309-322
Eskisehir Osmangazi University Affiliated: Yes

Abstract

The pathogenesis of cold-restraint stress ulcer involves various factors and is not completely understood, Mast cell degranulation, increased gastric muscular contractility, diminished mucosal blood flow release of several biogenic amines, activated polymorphonuclear leukocytes, and lipid peroxidation which results from toxic oxygen molecules were suggested to be related to the production of gastric damage by cold-restraint stress. Recent evidence strongly indicates that VIP has a modulatory effect on tissue injury.