In this study we aimed to investigate IL-8 levels in dyspeptic patients with Helicobacter pylori (H. pylori) infection and in control group. Our study group consists of 172 patients with dyspepsia who underwent upper gastrointestinal system endoscopy. On the day of taking gastric tissues, serum samples were taken. H. pylori were investigated from gastric tissues by invasive test methods as Gram staining, urease test and culture method. From serum samples anti-CagA IgA and IgG, anti-H. pylori IgM, IgA, IgG and IL-8 levels were studied by EIA. These 172 patients had positive invasive and/or serological test results. For the control group, 20 patients with negative H. pylori invasive and serological test results were included. Among 172 patients, 102 (59.3%) had normal IL-8 levels and 70 (40.7%) had high IL-8 levels. In 8 (40%) of 20 control patients IL-8 was high. The mean values of IL-8 were as 43.96 +/- 13.65 pg/ml (min-max: 0 - 1477 pg/ml) and 42.03 +/- 24.32 pg/ml (min-max: 0 - 483.6 pg/ml) in positive and negative groups, respectively. Our observations implicate that there was no significant difference in serum levels of IL-8 between H. pylori positive and negative patients.