Antioxidant status and lipid peroxidation in red blood cells of p-aminophenol-treated rats

Inal M., Kanbak G.

MEDICAL SCIENCE RESEARCH, cilt.25, sa.5, ss.323-325, 1997 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 5
  • Basım Tarihi: 1997
  • Dergi Adı: MEDICAL SCIENCE RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.323-325
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Some xenobiotics and drugs lead to reactive oxygen products. Erythrocytes have an important role in p-aminophenol (PAP) detoxification. We investigated erythrocyte antioxidant status and plasma lipid peroxidation in rats injected with PAP(200mgkg(-1)). Blood samples were obtained after 1, 24, 48, 72 and 96 h. Superoxide dismutase (SOD) activities decreased significantly in the PAP group within Ih while catalase (CAT) activities were lowered after 1 and 48 h. Glutathione reductase (GSSGR) activity in the PAP group was significantly high after 48, 72 and 96 h. Reduced glutathione (GSH) levels in the PAP group decreased after 1, 24, 48, 72 and 96 h. The plasma malondialdehyde (MDA) levels were significantly elevated in the PAP group after 24, 48, 72 and 96 h. Our findings indicate that PAP caused lipid peroxidation to increase and reduced glutathione levels to decline. SOD and CAT activities were lowered and GSSGR activities increased by PAP. Therefore, we believe that PAP may generate reactive oxygen products in erythrocytes.