Protective and therapeutic effect of Hydrogen sulfide on hemorrhagic cystitis and testis dysfunction induced with Cyclophosphamide.

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Özatİk F. Y., Özatİk O., TekŞen Y., YİĞİtaslan S., Ari N. S.

Turkish journal of medical sciences, vol.51, pp.1531-1543, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-2003-10
  • Journal Name: Turkish journal of medical sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1531-1543
  • Keywords: Cyclophosphamide, hydrogen sulfide, testis, bladder, BLADDER, H2S
  • Eskisehir Osmangazi University Affiliated: Yes


Backround/aim: Cyclophosphamide (CP) is a drug used for treatment of many malignant diseases. However, it can cause serious side effects such as hemorrhagic cystitis and male infertility. Hydrogen sulfide (H2S) is a gaseous mediator and is suggested to have antioxidant, antiinflammatory, and antiapoptotic effects. In this study, dose-dependent effects of H2S donor sodium hydrosulfide (NaHS) on cyclophosphamide-induced hemorrhagic cystitis and testicular dysfunction were investigated in rats.