Adsorption challenge in the PDMS-based microfluidic systems for drug screening application

Mohammadigharehbagh R., Tomsuk O., Ghorbanpoor H., Doğan Güzel F., Eker Sarıboyacı A., Avcı H.

11. Uluslararası Lif ve Polimer Araştırmaları Sempozyumu, Bursa, Türkiye, 4 - 05 Kasım 2022, ss.222-226

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Basıldığı Şehir: Bursa
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.222-226
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Drug screening is one of the demand areas due to close and direct dependency on human health. On the other hand, recently microfluidic systems have been increasingly used for drug development and screening purposes. However, this system has some challenges such as adsorption issue which can effect pharmacokinetic–pharmacodynamic (PK-PD) of the drugs. Thus, in this research, the issue was characterized and evaluated by UV-Vis spectrophotometry and FTIR spectroscopy devices as a model drug of cisplatin. Despite of strong relationship between logP and adsorption, and the very low value of logP in the drug candidate, the results for both apical and basal planes of the microfluidic chip confirmed the adsorption. In the UV-Vis spectrophotometry, the basal plane show 5%, and 10% higher adsorption compared to apical and control polydimethylsiloxane (PDMS)- based microfluidic. Additionally, the FTIR patterns were a good coincide with UV-Vis results.